MafB, a key genetic regulator that enables macrophages to reach full maturity and preserve the health of our organs, opening up new therapeutic avenues for treating numerous chronic diseases.

Macrophages adapt to different tissues while maintaining a shared identity, thanks to MafB, a key genetic regulator that directs their development and essential functions throughout the body.

Disrupting a key protein-production mechanism controlled by the KEOPS complex converts immune-resistant “cold” tumors into T-cell infiltrated “hot” tumors with strongly reduced growth in preclinical models.

The legal framework for research in organic chemistry is often poorly understood. This interdisciplinary tutorial article links laboratory practice with the law, providing researchers with guidance to balance innovation, safety and compliance.

A visible-light-driven photocatalytic method enables efficient formation of carbon–nitrogen bonds from simple carbonyl compounds, offering a sustainable approach for synthesising valuable amine-containing molecules.

A single-phase metal–organic framework exhibits simultaneous ion and electron conduction in the solid state, a rare property verified at room temperature, opening new possibilities for solid-state energy storage.

A manganese-based formulation allows oral delivery of anti-TNF-α antibodies, protecting them in the stomach and releasing them in the colon, offering an alternative to injections for treating inflammatory bowel disease.

Dysosmobacter welbionis, a gut bacterium linked to metabolic health, turns plant nutrients like myo-inositol into butyrate via a unique pathway. Less abundant in liver disease, it improves blood sugar and liver fat in diabetic and obese mice.

Copper, essential but toxic in excess, is normally sequestered within cells. The small ‘crab’-shaped molecule Cuphoralix releases intracellular copper from vesicles into the cytosol, causing toxic overload and cell death.

What a year it has been! WELRI now has 71 active programmes driving knowledge and impact in health and the sustainable transition, and the Walloon Government renewed its support to strategic research.

Thanks to all who made it possible!

Alessio Franci and colleagues were recognised for their major contribution to control systems theory based on a rigorous mathematical analysis of nonlinear opinion dynamics and individual sensitivity.

TMA, produced by gut bacteria from dietary choline, can help improve blood glucose control — a promising avenue in the fight against type 2 diabetes.